Journal
NPJ PRECISION ONCOLOGY
Volume 3, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41698-019-0080-7
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Funding
- National Institutes of Health, U.S.A. [CA187027, CA 166011, CA 196639]
- Key program of Henan Province, China [161100510300]
- National Natural Science Foundation of China [NSFC81672767]
- Henan Provincial Government, China
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The development of genetic engineering in the 1970s marked a new frontier in genome-editing technology. Gene-editing technologies have provided a plethora of benefits to the life sciences. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system is a versatile technology that provides the ability to add or remove DNA in the genome in a sequence-specific manner. Serious efforts are underway to improve the efficiency of CRISPR/Cas9 targeting and thus reduce off-target effects. Currently, various applications of CRISPR/Cas9 are used in cancer biology and oncology to perform robust site-specific gene editing, thereby becoming more useful for biological and clinical applications. Many variants and applications of CRISPR/Cas9 are being rapidly developed. Experimental approaches that are based on CRISPR technology have created a very promising tool that is inexpensive and simple for developing effective cancer therapeutics. This review discusses diverse applications of CRISPR-based gene-editing tools in oncology and potential future cancer therapies.
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