Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 3, Pages 1197-1203Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00778
Keywords
metal-organic frameworks; contrast agent; bismuth; X-ray computed tomography
Funding
- U.S. Department of Energy, National Nuclear Security Administration [DE-NA0003763]
- Toyota
- NCI CCSG [P30 CA060553]
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource [NSF ECCS-1542205]
- State of Illinois
- International Institute for Nanotechnology (IIN)
- MRSEC program at the Materials Research Center [NSF DMR-1720139]
- Keck Foundation
- State of Illinois, through the IIN
- NSF
- Nanjing Tech University
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A new bismuth metal-organic framework (MOF), bismuth-NU901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of similar to 11 angstrom, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi-6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates similar to 7 times better contrast intensity compared to a zirconium MOF featuring the same topology and similar to 14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.
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