Related references
Note: Only part of the references are listed.Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ
Barnabas Oche et al.
ARCHIVES OF PHARMACAL RESEARCH (2016)
Scavenger receptors and non-coding RNAs: relevance in atherogenesis
Yao Dai et al.
CARDIOVASCULAR RESEARCH (2016)
Heart Disease and Stroke Statistics-2016 Update A Report From the American Heart Association
Dariush Mozaffarian et al.
CIRCULATION (2016)
Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4-NF-κB Pathway
Guanwei Fan et al.
INFLAMMATION (2016)
Natural Product-Based Drug Discovery
Rongshi Li
MEDICINAL RESEARCH REVIEWS (2016)
Protocatechuic aldehyde inhibits TNF-α-induced fibronectin expression in human umbilical vein endothelial cells via a c-Jun N-terminal kinase dependent pathway
Yue-Feng Tong et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)
Cryptotanshinone inhibits oxidized LDL-induced adhesion molecule expression via ROS dependent NF-B pathways
Wenwen Zhao et al.
CELL ADHESION & MIGRATION (2016)
Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells
Shaowei Zhuang et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2016)
Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis
Qian Jiang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)
Tanshinone IIA affects the HDL subfractions distribution not serum lipid levels: Involving in intake and efflux of cholesterol
Lian-qun Jia et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)
Vascular endothelium - Gatekeeper of vessel health
Paul A. Cahill et al.
ATHEROSCLEROSIS (2016)
Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Ira Tabas et al.
CIRCULATION RESEARCH (2016)
Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease
Dhruv S. Kazi et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress
Kin Lung Siu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages
Shuli Ma et al.
JOURNAL OF ETHNOPHARMACOLOGY (2016)
Study on material base and action mechanism of compound Danshen dripping pills for treatment of atherosclerosis based on modularity analysis
Wei Zhou et al.
JOURNAL OF ETHNOPHARMACOLOGY (2016)
Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro
Zuraini Ahmad et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2016)
Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders
A. Janus et al.
MEDIATORS OF INFLAMMATION (2016)
The eNOS signalosome and its link to endothelial dysfunction
Mauro Siragusa et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)
Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health
Inthrani Raja Indran et al.
PHARMACOLOGY & THERAPEUTICS (2016)
Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells
Hung-Chen Chen et al.
PLOS ONE (2016)
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Sebastian Zimmer et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
Geena Paramel Varghese et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)
Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium
Wenwen Zhao et al.
FRONTIERS IN PHARMACOLOGY (2016)
Recent advances in the pharmacological management of hypercholesterolaemia
Ezim Ajufo et al.
LANCET DIABETES & ENDOCRINOLOGY (2016)
Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen)
Hongwei Gao et al.
SCIENTIFIC REPORTS (2016)
New Era of Lipid-Lowering Drugs
Philip J. Barter et al.
PHARMACOLOGICAL REVIEWS (2016)
Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration
Qingjie Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)
Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis
Li Shen et al.
ATHEROSCLEROSIS (2015)
Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA
Yan-Hua Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)
Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1)
Zhiping Liu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
A New Golden Age of Natural Products Drug Discovery
Ben Shen
CELL (2015)
Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway
Xin Liu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
Induction of Heme Oxygenase-1 by Sodium 9-Hydroxyltanshinone IIA Sulfonate Derivative Contributes to Inhibit LPS-Mediated Inflammatory Response in Macrophages
Xin-Hua Liu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
Inflammation and Immunity in Diseases of the Arterial Tree Players and Layers
Peter Libby et al.
CIRCULATION RESEARCH (2015)
Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome
Qinghua Hu et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)
P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation
Kuang Peng et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)
Tanshinone IIA Prevents Rat Basilar Artery Smooth Muscle Cells Proliferation by Inactivation of PDK1 During the Development of Hypertension
Zhi-Liang Yu et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2015)
Recent insights into the cellular biology of atherosclerosis
Ira Tabas et al.
JOURNAL OF CELL BIOLOGY (2015)
Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach
Jun Lu et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)
Establishment of an interleukin-1β-induced inflammation-activated endothelial cell-smooth muscle cell-mononuclear cell co-culture model and evaluation of the anti-inflammatory effects of tanshinone IIA on atherosclerosis
Yujie Li et al.
MOLECULAR MEDICINE REPORTS (2015)
Protective effects of tanshinone IIA on endothelial progenitor cells injured by tumor necrosis factor-α
Xing-Xiang Wang et al.
MOLECULAR MEDICINE REPORTS (2015)
The re-emergence of natural products for drug discovery in the genomics era
Alan L. Harvey et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts
Sung Bum Park et al.
PHARMACOLOGICAL RESEARCH (2015)
Nobel Prize for artemisinin brings phytotherapy into the spotlight
Thomas Efferth et al.
PHYTOMEDICINE (2015)
In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase
Meijuan Xu et al.
PHYTOMEDICINE (2015)
Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells
Yingying Xing et al.
ONCOLOGY REPORTS (2015)
Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming α subunit
Xiao-qiu Tan et al.
ACTA PHARMACOLOGICA SINICA (2014)
Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake
Xi Cheng et al.
BIOORGANIC CHEMISTRY (2014)
Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway
Minggang Chen et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity
Li Hong-zhan et al.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2014)
Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway
Li Wei et al.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2014)
Inflammation and its Resolution as Determinants of Acute Coronary Syndromes
Peter Libby et al.
CIRCULATION RESEARCH (2014)
A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
Timothy Kwok et al.
COMPLEMENTARY THERAPIES IN MEDICINE (2014)
Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients
James Cassuto et al.
DIABETES (2014)
Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis
Zhuo Chen et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)
OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation
Weiwei Liu et al.
INFLAMMATION RESEARCH (2014)
Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinone IIA from Danshen in a mouse model of atherosclerosis
Suowen Xu et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)
Rabbit Sera Containing Compound Danshen Dripping Pill Attenuate Leukocytes Adhesion to TNF-Alpha-Activated Human Umbilical Vein Endothelial Cells by Suppressing Endothelial ICAM-1 and VCAM-1 Expression Through NF-KappaB Signaling Pathway
Haibo Xu et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2014)
Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway
Francesco Maione et al.
JOURNAL OF ETHNOPHARMACOLOGY (2014)
Lipid-lowering effects of Danhong injection on hyperlipidemia rats
Juan Chen et al.
JOURNAL OF ETHNOPHARMACOLOGY (2014)
Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1
Zhiping Liu et al.
JOURNAL OF LIPID RESEARCH (2014)
PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes
Rajiv Lochan Tiwari et al.
JOURNAL OF LIPID RESEARCH (2014)
Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications
Suowen Xu et al.
MEDICINAL RESEARCH REVIEWS (2014)
The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
Xiuping Chen et al.
MEDICINAL RESEARCH REVIEWS (2014)
The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression
Cheng-Chieh Chang et al.
PHYTOMEDICINE (2014)
Sodium Tanshinone IIA Silate Inhibits High Glucose-Induced Vascular Smooth Muscle Cell Proliferation and Migration through Activation of AMP-Activated Protein Kinase
Wen-yu Wu et al.
PLOS ONE (2014)
Swimming Against the Tide: Drugs Drive Neutrophil Reverse Migration
Christopher D. Lucas et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism
Anne L. Robertson et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Dendritic cells in atherosclerosis
Manikandan Subramanian et al.
SEMINARS IN IMMUNOPATHOLOGY (2014)
Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling
Tao Shang et al.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE (2014)
Tanshinone IIA promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphatidylinositol 3-kinase/Akt
Chun Shi et al.
BIOMEDICAL REPORTS (2014)
Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats
Jian Wang et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins
Wenli Zhang et al.
BIOMATERIALS (2013)
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Suowen Xu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
Patrick W. F. Hadoke et al.
CURRENT ATHEROSCLEROSIS REPORTS (2013)
Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease
Huige Li et al.
CURRENT OPINION IN PHARMACOLOGY (2013)
Naoxintong Protects against Atherosclerosis through Lipid-lowering and Inhibiting Maturation of Dendritic Cells in LDL Receptor Knockout Mice fed a High-fat Diet
Jingjing Zhao et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Therapeutic Effects of Water Soluble Danshen Extracts on Atherosclerosis
Yoon Hee Cho et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)
Tanshinone II-A: new perspectives for old remedies
Suowen Xu et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
Tiina Kipari et al.
FASEB JOURNAL (2013)
TANSHINONE VI INHIBITS THE EXPRESSION OF INTERCELLULAR ADHESION MOLECULE-1 AND VASCULAR CELL ADHESION MOLECULE-1
V. Nicolin et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2013)
Vascular Reactivity Screen of Chinese Medicine Danhong Injection Identifies Danshensu as a NO-Independent but PGI2-Mediated Relaxation Factor
Dandan Wang et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2013)
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
Mingjuan J. Luo et al.
PHYSIOLOGICAL GENOMICS (2013)
Pharmacological tools for the development of traditional Chinese medicine
Xuan Liu et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Tanshinone IIA Attenuates H2O2-Induced Injury in Human Umbilical Vein Endothelial Cells
Paul Chan et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2012)
Cardiovascular actions and therapeutic potential of tanshinone IIA
Si Gao et al.
ATHEROSCLEROSIS (2012)
Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner
Yi Bao et al.
ATHEROSCLEROSIS (2012)
Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells
Hong-Jye Hong et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2012)
Nitric oxide synthases: regulation and function
Ulrich Foerstermann et al.
EUROPEAN HEART JOURNAL (2012)
Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926
Zhi-Wei Zhou et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress
Wenying Chen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities
Yong Zhang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages
Seung Eun Lee et al.
JOURNAL OF ETHNOPHARMACOLOGY (2012)
Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells
Lian-qun Jia et al.
JOURNAL OF ETHNOPHARMACOLOGY (2012)
Inhibition of experimental abdominal aortic aneurysm in a rat model by way of tanshinone IIA
Tao Shang et al.
JOURNAL OF SURGICAL RESEARCH (2012)
Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NE-κB activation
Suowen Xu et al.
TRANSLATIONAL RESEARCH (2012)
Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities
Yeonsoo Joe et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet
Suowen Xu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)
Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells
Ming-Yen Tsai et al.
CANCER LETTERS (2011)
Tanshinone IIA attenuates atherosclerosis in ApoE-/- mice through down-regulation of scavenger receptor expression
Fu-Tian Tang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways
Shu Tang et al.
INFLAMMATION (2011)
Cryptotanshinone inhibits LPS-induced proinflammatory mediators via TLR4 and TAK1 signaling pathway
Xin Li et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2011)
Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model
Wen-Li Zhang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)
Direct Vasorelaxation by a Novel Phytoestrogen Tanshinone IIA Is Mediated by Nongenomic Action of Estrogen Receptor Through Endothelial Nitric Oxide Synthase Activation and Calcium Mobilization
Guanwei Fan et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2011)
Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits
Tung-Lin Yang et al.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2011)
Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents
Yizhou Dong et al.
NATURAL PRODUCT REPORTS (2011)
Progress and challenges in translating the biology of atherosclerosis
Peter Libby et al.
NATURE (2011)
Cryptotanshinone Attenuates In Vitro oxLDL-Induced Pre-Lesional Atherosclerotic Events
Kok-Pian Ang et al.
PLANTA MEDICA (2011)
Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis
Peter J. Little et al.
PHARMACOLOGY & THERAPEUTICS (2011)
AMPK and vasculoprotection
Marie-Ann Ewart et al.
PHARMACOLOGY & THERAPEUTICS (2011)
A Simplified and High-Throughput Chromogenic Assay for Testing Tissue Factor-Dependent Procoagulant Activity
Wenwen Jiang et al.
JOURNAL OF BIOMOLECULAR SCREENING (2011)
Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia
Rui-xue Yang et al.
ACTA PHARMACOLOGICA SINICA (2010)
Soluble Epoxide Hydrolase in Atherosclerosis
Yi-Xin Jim Wang et al.
CURRENT ATHEROSCLEROSIS REPORTS (2010)
Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway
Xin Li et al.
JOURNAL OF ETHNOPHARMACOLOGY (2010)
Endothelial precursors in vascular repair
John Paul Kirton et al.
MICROVASCULAR RESEARCH (2010)
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell et al.
NATURE (2010)
Seeing the future of bioactive lipid drug targets
Jilly F. Evans et al.
NATURE CHEMICAL BIOLOGY (2010)
Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension
Jian Fang et al.
PHYTOMEDICINE (2010)
Macrophage death and defective inflammation resolution in atherosclerosis
Ira Tabas
NATURE REVIEWS IMMUNOLOGY (2010)
Is thrombin a key player in the 'coagulation-atherogenesis' maze?
Julian Ilcheff Borissoff et al.
CARDIOVASCULAR RESEARCH (2009)
Antidiabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis
D. J. Lloyd et al.
DIABETES OBESITY & METABOLISM (2009)
The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
Guan-Wei Fan et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)
Modulation of endothelial nitric oxide by plant-derived products
Christoph A. Schmitt et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2009)
Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo
Weipeng Bian et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza Bunge
Su Jin Jeon et al.
ARCHIVES OF PHARMACAL RESEARCH (2008)
Hyperelongated biglycan: the surreptitious initiator of atherosclerosis
Peter J. Little et al.
CURRENT OPINION IN LIPIDOLOGY (2008)
Tanshinone IIA From Salvia miltiorrhiza BUNGE inhibits Human Aortic Smooth Muscle Cell Migration and MMP-9 Activity Through AKT Signaling Pathway
Un-Ho Jin et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels
Francis F. Y. Lam et al.
JOURNAL OF ETHNOPHARMACOLOGY (2008)
Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit
Zhi-Yuan Fang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2008)
Vascular Effects of Different Lipophilic Components of Danshen, a Traditional Chinese Medicine, in the Isolated Porcine Coronary Artery
Alan K. S. Wan et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase
Yu-I Li et al.
LIFE SCIENCES (2008)
Translating molecular discoveries into new therapies for atherosclerosis
Daniel J. Rader et al.
NATURE (2008)
Antiatherogenic property of triterpenoids-enriched extract from the aerial parts of Salvia miltiorrhiza
Qin Zhang et al.
PHYTOTHERAPY RESEARCH (2008)
Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging
Ke-Jing Huang et al.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2007)
Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet
Zhi-yuan Fang et al.
LIFE SCIENCES (2007)
Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis
Chao Tang et al.
ACTA PHARMACOLOGICA SINICA (2007)
Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress
Futian Tang et al.
VASCULAR PHARMACOLOGY (2007)
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
Hong-Sheng Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension
David D. Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinfiammatory mediator, high mobility group box 1
Wei Li et al.
JOURNAL OF IMMUNOLOGY (2007)
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
Peter F. Mount et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells
Shing-Jong Lin et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells
Tso-Hsiao Chen et al.
MITOCHONDRION (2007)
New developments in the chemistry and biology of the bioactive constituents of Tanshen
Xihong Wang et al.
MEDICINAL RESEARCH REVIEWS (2007)
Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1
Seok-Jong Suh et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism
Rong Lin et al.
JOURNAL OF ETHNOPHARMACOLOGY (2006)
Tanshinone IIA inhibits LPS-induced NF-κB activation in RAW 264.7 cells:: Possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways
Seon Jang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Insulin resistance and atherosclerosis
J Nigro et al.
ENDOCRINE REVIEWS (2006)
Angiogenesis: from plants to blood vessels
Tai-Ping Fan et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells
Z Zhou et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)
Rho GTPases, statins, and nitric oxide
Y Rikitake et al.
CIRCULATION RESEARCH (2005)
Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
LM Zhou et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2005)
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
A Hermanowski-Vosatka et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
K Chalupsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice
JR Du et al.
JOURNAL OF ETHNOPHARMACOLOGY (2005)
Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCα
I Fleming et al.
CARDIOVASCULAR RESEARCH (2005)
Homocysteine induces oxidative, stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin
G Topal et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation
AB El-Remessy et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)
Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
BR Kwak et al.
CIRCULATION (2003)
Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation
BB Davis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
BJ Michell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza
BY Kang et al.
IMMUNOPHARMACOLOGY (2000)