Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 26, Issue 11, Pages 3038-3045Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-017-2001-z
Keywords
NSAIDs; Fenamates; Amides; Wnt/beta-catenin; Cancer
Categories
Funding
- National Institutes of Health NCI [1R01CA131378, RO1CA124531]
- University of Alabama at Birmingham, Department of Hematology and Oncology
- DOD Era of Hope award [W81XWH-07-1-0463]
Ask authors/readers for more resources
As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/beta-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/beta-catenin signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available