Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 26, Issue 12, Pages 3209-3215Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-017-2014-7
Keywords
Artemisia dracunculus L.; Asteraceae; alpha-glucosidase inhibition; alpha-amylase inhibition
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Funding
- Foundation of Ataturk University [2015/324]
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A new phenylpropanoid named 4-(1',1',2',2'-tetramethylpropyl)-1,2-benzenediol (1) with a known phenylpropanoid: 3-(p-methoxyphenyl)-1,2-propanediol (2), a coumarin: herniarin (3), and a flavonol glycoside: rutin (4) were isolated from the aerial parts of Artemisia dracunculus L. Their structures were elucidated by detailed analyses of 1D and 2D nuclear magnetic resonance, IR, ESI-MS and HR-ESI-MS data. Methanol extract of aerial parts of the plant, different polarity fractions of methanol extract and the isolated compounds from these fractions were evaluated for their alpha amylase and alpha glucosidase inhibitory effects. Phenylpropanoids containing fraction had a significantly higher alpha-glucosidase inhibitory activity (90.4%) when compared with the standart compound acarbose (26.0%) at 1 mg/mL. However none of the tested extracts or compounds were found to be active on alpha-amylase inhibition.
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