Journal
LIFE SCIENCES IN SPACE RESEARCH
Volume 20, Issue -, Pages 113-123Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.lssr.2018.10.004
Keywords
Space radiation; Microgravity; Combined effects; DNA oxidative damage; Signal transduction
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In the mid-1980s, space experiments began to examine if microgravity could alter the biological effects of space radiation. In the late 1990s, repair of DNA strand breaks was reported to not be influenced by microgravity using the pre-irradiated cells, because the exposure doses of space radiation were few due to the short spaceflight. There were, however, conflicting reports depending on the biological endpoints used in various systems. While almost no attempts were made to assess the possibility that the microgravity effects could be altered by space radiation. This was probably due to the general understanding that microgravity plays a major role in space and works independently from space radiation. Recent ground-based simulation studies focusing on DNA oxidative damage and signal transduction suggested that combined effects of microgravity and space radiation might exist. These studies also implicated the importance of research focusing not only on chromosomal DNA but also on cytoplasm, especially mitochondria. Therefore, we propose a new model which accounts for the combined-effects through the window of cellular responses. In this model, the interactions between microgravity and space radiation might occur during the following cellular-responses; (A) damaging and signaling by ROS, (B) damage responses on DNA (repair, replication, transcription, etc.), and (C) expression of gene and protein (regulation by chromatin, epigenetic control, etc.).
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