Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 10, Pages 2818-2823Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00097f
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Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines via SN1 type processes in good to excellent yields are reported. Sterically demanding phenol substrates such as 2,6-diphenylphenol gave novel aryl substituted products via electrophilic aromatic substitution.
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