Journal
MEDICAL ONCOLOGY
Volume 34, Issue 3, Pages -Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-017-0888-3
Keywords
FoxM1; Cell regulation; Breast cancer; Targeting therapy
Categories
Funding
- National Nature Science Foundation of China [21405138, 81273111]
- Scientific Projects of Zhejiang Province [2015C33148, 2015C37117]
- Foundations of Innovative Research Team of Educational Commission of Zhejiang Province [T200907]
- Ningbo Scientific Innovation Team for Environmental Hazardous Factor Control and Prevention [2016C51001]
- KC Wong Magna Fund in Ningbo University
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Forkhead box M1 (FoxM1) is an oncogenic transcription factor involved in a wide variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism and DNA damage response. It is overexpressed in many human cancers, especially in breast cancers. Posttranslational modifications are known to play an important role in regulating the expression and transcriptional activity of FoxM1. In this review, we characterize the posttranslational modifications of FoxM1, summarize modifications of FoxM1 by different kinases, explore the relationship between the different sites of modifications and comprehensively describe how post-translational modifications to regulate the function of FoxM1 by changing protein stability, nucleus localization and transcriptional activity. Additionally, we systematically summarize the roles of FoxM1 in breast cancer occurrence, therapy and drug resistance. The purpose of this paper tries to give a better understanding of the regulatory mechanisms of FoxM1 in cell regulation and highlights potential of a new method for breast cancer therapy by targeting FoxM1.
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