Journal
BIOMOLECULES
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/biom9020056
Keywords
curcumin; nanoparticles; inflammation; protein aggregation; brain diseases; Alzheimer's disease; Parkinson's disease
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Funding
- Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico (Becas Posdoctorales) [PAPIIT TA 200318]
- Consejo Nacional de Ciencia y Tecnologia [526864]
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Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms curcumin and curcumin brain diseases, which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.
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