4.7 Article

A visible light photoredox catalyzed carbon radical-mediated generation of ortho-quinone methides for 2,3-dihydrobenzofuran synthesis

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 21, Pages 3117-3120

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc00727j

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Funding

  1. NNSF of China [91856119, 21622201, 21820102003, 21772053]
  2. Science and Technology Department of Hubei Province [2016CFA050, 2017AHB047]
  3. Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]

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A visible light photoredox-catalyzed carbon radical-mediated strategy for in situ formation of ortho-quinone methides from 2-vinyl phenols is described. This strategy enables a multicomponent cyclization reaction of 2-vinyl phenols, Umemoto's reagent, and sulfur ylides, providing access to trifluoromethylated 2,3-dihydrobenzofurans.

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