Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 21, Pages 3089-3092Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc00434c
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- Recruitment Program of Global Experts (1000 Talents Plan)
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Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance and atom economy, and various heteroatom-containing evodiamine analogues are obtained in moderate to excellent yields even on a gram scale. An anti-tumor study in vitro demonstrates compound 2b possesses potent efficacy against hepatoma cell line (IC50 = 5.7 mu M).
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