Related references
Note: Only part of the references are listed.Phosphatidylserine Stimulates Ceramide 1-Phosphate (C1P) Intermembrane Transfer by C1P Transfer Proteins
Xiuhong Zhai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ
Amandeep Bajwa et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking
Santiago Lima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Inflammatory mechanisms linking obesity and metabolic disease
Alan R. Saltiel et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling
Emily V. Mesev et al.
MOLECULAR PHARMACOLOGY (2017)
Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia
Aida Zulueta et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2017)
Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination
Wen-Na Shi et al.
ONCOTARGET (2017)
Novel pleiotropic effects of bioactive phospholipids in human lung cancer metastasis
Gabriela Schneider et al.
ONCOTARGET (2017)
Sphingosine 1-Phosphate: A Novel Target for Lung Disorders
Sabira Mohammed et al.
FRONTIERS IN IMMUNOLOGY (2017)
Inhibitory Effects of Novel SphK2 Inhibitors on Migration of Cancer Cells
Euiyeon Lee et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2017)
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors
Carolyn D. Britten et al.
CLINICAL CANCER RESEARCH (2017)
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2
Guowei Zhang et al.
CANCER CELL INTERNATIONAL (2017)
Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival
Aparna Maiti et al.
CELLULAR SIGNALLING (2017)
Sphingolipids in mitochondria
Maria Jose Hernandez-Corbacho et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)
Suppression of NLRP3 inflammasome by gamma-tocotrienol ameliorates type 2 diabetes
Yongeun Kim et al.
JOURNAL OF LIPID RESEARCH (2016)
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer
Wei Liu et al.
TUMOR BIOLOGY (2016)
被撤回的出版物: Down-regulation of Sphk2 suppresses bladder cancer progression (Retracted article. See April, 2017)
Erlin Sun et al.
TUMOR BIOLOGY (2016)
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543
TongFa Ju et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor
Shuhong Guan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Priming with ceramide-1 phosphate promotes the therapeutic effect of mesenchymal stem/stromal cells on pulmonary artery hypertension
Jisun Lim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells
Io-Guane Rivera et al.
BIOCHEMICAL PHARMACOLOGY (2016)
Regulation of cell migration and inflammation by ceramide 1-phosphate
Natalia Presa et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)
CERK might contribute to inflammatory pain; Comments on Yu WL, Sun. Y (2015). CERK inhibition might be a good potential therapeutic target for diseases. Br J Pharmacol 172: 2165
Jin-lu Huang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Targeting Inflammation in Cancer Prevention and Therapy
Jelena Todoric et al.
CANCER PREVENTION RESEARCH (2016)
Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration
Marta Ordonez et al.
CELLULAR SIGNALLING (2016)
Sphingosine kinase inhibitors: a review of patent literature (2006-2015)
Kevin R. Lynch et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2016)
Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors
Sebastian Katz et al.
IMMUNOLOGY LETTERS (2016)
C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-κB Activation in Neutrophils
Kristin Baudiss et al.
JOURNAL OF IMMUNOLOGY (2016)
ORMDL proteins regulate ceramide levels during sterile inflammation
Lin Cai et al.
JOURNAL OF LIPID RESEARCH (2016)
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis
Junko Tsuchida et al.
JOURNAL OF SURGICAL RESEARCH (2016)
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis
Hiroaki Aoki et al.
JOURNAL OF SURGICAL RESEARCH (2016)
High levels of sphingolipids in human breast cancer
Masayuki Nagahashi et al.
JOURNAL OF SURGICAL RESEARCH (2016)
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances
Susan Pyne et al.
PROGRESS IN LIPID RESEARCH (2016)
Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate
Antonio Gomez-Munoz et al.
PROGRESS IN LIPID RESEARCH (2016)
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression
Lan Zhang et al.
TUMOR BIOLOGY (2016)
An oncogenic role for sphingosine kinase 2
Heidi A. Neubauer et al.
ONCOTARGET (2016)
Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640
Clayton S. Lewis et al.
ONCOTARGET (2016)
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
Melissa McNaughton et al.
ONCOTARGET (2016)
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells
Xiwei Ding et al.
ONCOTARGET (2016)
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
Georgios Grammatikos et al.
ONCOTARGET (2016)
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection
Irina V. Tiper et al.
PATHOGENS AND DISEASE (2016)
Sphingosine-1 Phosphate: A New Modulator of immune Plasticity in the Tumor Microenvironment
Yamila I. Rodriguez et al.
FRONTIERS IN ONCOLOGY (2016)
Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence
Baasanjav Uranbileg et al.
PLOS ONE (2016)
Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human
Masaya Sato et al.
SCIENTIFIC REPORTS (2016)
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice
Xia Gao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
CERK inhibition might be a good potential therapeutic target for diseases
Wei-Li Yu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer
Jie Yang et al.
CANCER BIOLOGY & THERAPY (2015)
THE EFFECT OF THE BIOACTIVE SPHINGOLIPIDS S1P AND C1P ON MULTIPOTENT STROMAL CELLS - NEW OPPORTUNITIES IN REGENERATIVE MEDICINE
Krzysztof Marycz et al.
CELLULAR & MOLECULAR BIOLOGY LETTERS (2015)
Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation
Kristin Baudiss et al.
EUROPEAN RESPIRATORY JOURNAL (2015)
Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy
Jason Newton et al.
EXPERIMENTAL CELL RESEARCH (2015)
Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes
Lara Bellini et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2015)
Role of sphingomyelinases in neurological disorders
Wei-Yi Ong et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2015)
Conjugated Bile Acid-Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression
Masayuki Nagahashi et al.
HEPATOLOGY (2015)
Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice
Clement Oyeniran et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses
Carole A. Oskeritzian et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor
Naoki Mizutani et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2015)
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo
Cai Xun et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)
Very-long-chain fatty acid sphingomyelin in nuclear lipid microdomains of hepatocytes and hepatoma cells: can the exchange from C24:0 to C16:0 affect signal proteins and vitamin D receptor?
Andrea Lazzarini et al.
MOLECULAR BIOLOGY OF THE CELL (2015)
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo
Heather Venant et al.
MOLECULAR CANCER THERAPEUTICS (2015)
SPHINGOSINE KINASE 2 AND SPHINGOSINE-1-PHOSPHATE PROMOTES MITOCHONDRIAL FUNCTION IN DOPAMINERGIC NEURONS OF MOUSE MODEL OF PARKINSON'S DISEASE AND IN MPP+-TREATED MN9D CELLS IN VITRO
M. Sivasubramanian et al.
NEUROSCIENCE (2015)
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
Shanmugam Panneer Selvam et al.
SCIENCE SIGNALING (2015)
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
Io-Guane Rivera et al.
TOXINS (2015)
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
Shanmugam Panneer Selvam et al.
SCIENCE SIGNALING (2015)
Sphingosine kinase 2-deficiency mediated changes in spinal pain processing
Jastrow Canlas et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer
N. C. Hait et al.
ONCOGENESIS (2015)
Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation
Chih-Kai Hsu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
被撤回的出版物: SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma (Retracted article. See April, 2017)
Zijie Zhang et al.
TUMOR BIOLOGY (2015)
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma
J. Kummetha Venkata et al.
BLOOD (2014)
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death
Oleksandr Pastukhov et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Ania W. Payne et al.
CANCER RESEARCH (2014)
Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression
Craig T. Wallington-Beddoe et al.
CANCER RESEARCH (2014)
Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts
Oleksandr Pastukhov et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy
Diem-Hang Nguyen-Tran et al.
DISEASE MODELS & MECHANISMS (2014)
The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells
Mariusz Z. Ratajczak et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2014)
DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells
Kan Chen et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs
Emilie Begagne et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
Dayanjan S. Wijesinghe et al.
JOURNAL OF LIPID RESEARCH (2014)
Export of sphingosine-1-phosphate and cancer progression
Kazuaki Takabe et al.
JOURNAL OF LIPID RESEARCH (2014)
The Role of Sphingolipids in Arachidonic Acid Metabolism
Hiroyuki Nakamura et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2014)
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neurons by activation of ceramide kinase
Stepan Aleshin et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2014)
Sphingolipid metabolites in inflammatory disease
Michael Maceyka et al.
NATURE (2014)
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5
Kuzhuvelil B. Harikumar et al.
NATURE IMMUNOLOGY (2014)
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
Nitai C. Hait et al.
NATURE NEUROSCIENCE (2014)
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival
Matthew M. Gestaut et al.
PHARMACOLOGICAL REPORTS (2014)
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer
Qiushi Wang et al.
TUMOR BIOLOGY (2014)
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer
Arpita Datta et al.
ONCOTARGET (2014)
Effect of Eriodictyol on the Development of Atopic Dermatitis-Like Lesions in ICR Mice
Sae-Jin Park et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
Jie Liang et al.
CANCER CELL (2013)
Plasma Sphingolipids and Lung Cancer: A Population-Based, Nested Case-Control Study
Anthony J. Alberg et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2013)
Nuclear Lipid Microdomain as Place of Interaction between Sphingomyelin and DNA during Liver Regeneration
Elisabetta Albi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma
Megan M. Price et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation
Mohamad M. Adada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
Yuquan Xiong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy
Gabriela Schneider et al.
MOLECULAR CANCER RESEARCH (2013)
Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids
Dhirendra K. Simanshu et al.
NATURE (2013)
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
Gregory T. Kunkel et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent
Kai Liu et al.
PLOS ONE (2013)
Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability
Karen Rex et al.
PLOS ONE (2013)
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis
DeAnna A. Baker et al.
RHEUMATOLOGY INTERNATIONAL (2013)
Ceramide-1-Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells-Implications for Tissue Regeneration
Chihwa Kim et al.
STEM CELLS (2013)
Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis
Wei-Ching Huang et al.
BIOMOLECULES (2013)
Building a better sphingosine kinase-1 inhibitor
Kevin R. Lynch
BIOCHEMICAL JOURNAL (2012)
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
Mark E. Schnute et al.
BIOCHEMICAL JOURNAL (2012)
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer
J. Ohotski et al.
BRITISH JOURNAL OF CANCER (2012)
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection
J. Nunes et al.
BRITISH JOURNAL OF CANCER (2012)
Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression
De-Fu Sun et al.
CANCER LETTERS (2012)
Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis
Masayuki Nagahashi et al.
CANCER RESEARCH (2012)
Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis
Jerry E. Chipuk et al.
CELL (2012)
Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
Brian M. Barth et al.
CELLULAR SIGNALLING (2012)
Ceramide kinase deficiency improves diet-induced obesity and insulin resistance
Susumu Mitsutake et al.
FEBS LETTERS (2012)
New signalling pathway involved in the anti-proliferative action of vitamin D3 and its analogues in human neuroblastoma cells. A role for ceramide kinase
Francesca Bini et al.
NEUROPHARMACOLOGY (2012)
Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases
Peng Gao et al.
PLOS ONE (2012)
Sphingosine-1-phosphate signaling and its role in disease
Michael Maceyka et al.
TRENDS IN CELL BIOLOGY (2012)
Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers
Susan Pyne et al.
FRONTIERS IN ONCOLOGY (2012)
Inflammation as common soil of the multifactorial diseases
Rossana Scrivo et al.
AUTOIMMUNITY REVIEWS (2011)
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection
Ludovic Gomez et al.
BASIC RESEARCH IN CARDIOLOGY (2011)
Extracellular and intracellular sphingosine-1-phosphate in cancer
Jessie W. Yester et al.
CANCER AND METASTASIS REVIEWS (2011)
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
Vladimir Beljanski et al.
CANCER BIOLOGY & THERAPY (2011)
Targeting NFκB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2
James W. Antoon et al.
CANCER BIOLOGY & THERAPY (2011)
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
Graham M. Strub et al.
FASEB JOURNAL (2011)
All Trans Retinoic Acid and Cancer
Siddikuzzaman et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2011)
Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression
Jody L. Hankins et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
William L. Holland et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells
Andrew J. Kennedy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Bolormaa Vandanmagsar et al.
NATURE MEDICINE (2011)
Ceramide induces serotonin release from RBL-2H3 mast cells through calcium mediated activation of phospholipase A2
Jung Eun Ji et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2011)
Modulation of ceramide metabolism in mouse primary macrophages
Philipp Rovina et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Intranuclear sphingomyelin is associated with transcriptionally active chromatin and plays a role in nuclear integrity
Catia Scassellati et al.
BIOLOGY OF THE CELL (2010)
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
Alexander A. Chumanevich et al.
CARCINOGENESIS (2010)
Inflammation 2010: New Adventures of an Old Flame
Ruslan Medzhitov
CELL (2010)
Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-α Production Induced by Lipopolysaccharide
Szczepan Jozefowski et al.
JOURNAL OF IMMUNOLOGY (2010)
ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI
Masashi Murakami et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
Eiko Tada et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2010)
Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2
Kevin J. French et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Orm family proteins mediate sphingolipid homeostasis
David K. Breslow et al.
NATURE (2010)
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Sergio E. Alvarez et al.
NATURE (2010)
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Miriam F. Moffatt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation
Susumu Mitsutake et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2010)
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Sphingosine 1-phosphate and cancer
Nigel J. Pyne et al.
NATURE REVIEWS CANCER (2010)
Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains
Philipp Rovina et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)
Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor
Maria H. Granado et al.
CELLULAR SIGNALLING (2009)
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
Andreas Weigert et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A2
Albert Gubern et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
Eugen Ruckhaeberle et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2009)
Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis
Wen-Qi Lai et al.
JOURNAL OF IMMUNOLOGY (2009)
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
Hitoshi Ikeda et al.
JOURNAL OF LIPID RESEARCH (2009)
Chain length specificity for activation of cPLA2α by C1P: use of the dodecane delivery system to determine lipid-specific effects
Dayanjan S. Wijesinghe et al.
JOURNAL OF LIPID RESEARCH (2009)
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
Nitai C. Hait et al.
SCIENCE (2009)
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model
Teruaki Nishiuma et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
N,N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells
Hyo-Lim Kim et al.
ARCHIVES OF PHARMACAL RESEARCH (2008)
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
Steven W. Paugh et al.
BLOOD (2008)
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions
Carole A. Oskeritzian et al.
BLOOD (2008)
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
Dai Shida et al.
CANCER RESEARCH (2008)
Ceramide 1-phosphate stimulates macrophage activation of the PI3-kinase/PKB, JNK and proliferation through ERK1/2 pathways
Patricia Gangoiti et al.
CELLULAR SIGNALLING (2008)
Ceramide kinase and the ceramide-1-phosphate/cPLA2 interaction as a therapeutic target
Nadia F. Lamour et al.
CURRENT DRUG TARGETS (2008)
Targeting SphK1 as a new strategy against cancer
Dai Shida et al.
CURRENT DRUG TARGETS (2008)
Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice
Christine Graf et al.
JOURNAL OF IMMUNOLOGY (2008)
Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis
Wen-Qi Lai et al.
JOURNAL OF IMMUNOLOGY (2008)
Origin and physiological roles of inflammation
Ruslan Medzhitov
NATURE (2008)
Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease
Peter Libby
NUTRITION REVIEWS (2008)
Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase - Comparative analysis to glucosylceramide and sphingomyelin
Alistair Boath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Macrophage infiltration into adipose tissue: initiation, propagation and remodeling
Bonnie K. Surmi et al.
FUTURE LIPIDOLOGY (2008)
Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation
Hirotaka Kumada et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
Miriam F. Moffatt et al.
NATURE (2007)
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
Nadia F. Lamour et al.
JOURNAL OF LIPID RESEARCH (2007)
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells
Poularal Mitra et al.
FEBS LETTERS (2007)
Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus
Mihaela Dragusin et al.
FASEB JOURNAL (2006)
Ceramide-1-phosphate activates cytosolic phospholipase A2α directly and by PKC pathway
H Nakamura et al.
BIOCHEMICAL PHARMACOLOGY (2006)
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses
A Olivera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
CE Chalfant et al.
JOURNAL OF CELL SCIENCE (2005)
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells:: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators
A Billich et al.
CELLULAR SIGNALLING (2005)
The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity
TJ Kim et al.
FEBS LETTERS (2005)
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate
BJ Pettus et al.
MOLECULAR PHARMACOLOGY (2005)
Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway
A Gómez-Muñoz et al.
FEBS LETTERS (2005)
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases
JW Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells
S Mitsutake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ceramide-1-phosphate:: a novel regulator of cell activation
A Gómez-Muñoz
FEBS LETTERS (2004)
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
BJ Pettus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sphingosine I-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation
H Ikeda et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Molecular machinery for non-vesicular trafficking of ceramide
K Hanada et al.
NATURE (2003)
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
N Igarashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release
BJ Pettus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Sphingosine kinase transmits estrogen signaling in human breast cancer cells
OA Sukocheva et al.
MOLECULAR ENDOCRINOLOGY (2003)
Reverse sphingomyelin-synthase in rat liver chromatin
E Albi et al.
FEBS LETTERS (2003)
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α
BJ Pettus et al.
FASEB JOURNAL (2003)
Sphingosine-1-phosphate: An enigmatic signalling lipid
S Spiegel et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5
H Ikeda et al.
GASTROENTEROLOGY (2003)
Ceramide kinase, a novel lipid kinase - Molecular cloning and functional characterization
M Sugiura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
H Birbes et al.
FASEB JOURNAL (2001)
Share Paper
