Journal
MEDIATORS OF INFLAMMATION
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/7353252
Keywords
-
Categories
Funding
- SIRIC ONCOLille
- national agency of research development in health (ATRSS)
- Agence Universitaire de la Francophonie
Ask authors/readers for more resources
Colitis associated cancer (CAC) is the colorectal cancer (CRC) subtype that is associated with bowel disease such as ulcerative colitis (UC). The data on role of NF-kappa B signaling in development and progression of CAC were derived from preclinical studies, whereas data from human are rare. The aim of this work was to study the contribution of NF-kappa B pathway during UC and CAC, as well as the immunomodulatory effect of all-trans retinoic acid (AtRA). We analyzed the expression of NOS2, TNF-alpha, TLR4, and NF-kappa B, in colonic mucosa. We also studied NO/TNF-alpha modulation by LPS in colonic mucosa pretreated with AtRA. A marked increase in TLR4, NF-kappa B, TNF-alpha, and NOS2 expression was reported in colonic mucosa. The relationship between LPS/TLR4 and TNF-alpha/NO production, as well as the role of NF-kappa B signaling, was confirmed by ex vivo experiments and the role of LPS/TLR4 in NOS2/TNF- alpha induction through NF-kappa B pathway was suggested. AtRA downregulates NOS2 and TNF-alpha expression. Collectively, our study indicates that AtRA modulates in situ LPS/TLR4/NF-kappa B signaling pathway targeting NOS2 and TNF-alpha expression. Therefore, we suggest that AtRA has a potential value in new strategies to improve the current therapy, as well as in the clinical prevention of CAC development and progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available