Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 24, Pages 3556-3559Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01113g
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Funding
- AMED [JP18am0101098, JP18am0301024]
- JSPS [JP15H03118, JP18H02104, JP16H01133, JP18H04386, JP17H06414, JP26350971, JP18H04568, JP18J11113, JP17K13266]
- Cooperative Research Project of Research Center for Biomedical Engineering
- Naito Foundation
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A facile method for preparing various functional cycloalkynes, including proteins incorporated with a cycloalkyne moiety, from the corresponding azides is developed. Treatment of diynes bearing strained and terminal alkyne moieties with a copper salt enabled terminal alkyne-selective click conjugation with azides, whereas a more azidophilic strained alkyne moiety was transiently protected from the click reaction via complexation with copper.
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