Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00594
Keywords
mRNA vaccine; infectious disease; delivery; mechanism; application
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Funding
- Priority Academic Talent Team Cultivation Program of Shandong Colleges and Universities
- Talent Program of Qingdao Agricultural University
- National ThirteenFive Key research and development program of China [2017YFD0500805]
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During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.
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