Journal
MECHANISMS OF DEVELOPMENT
Volume 143, Issue -, Pages 9-19Publisher
ELSEVIER
DOI: 10.1016/j.mod.2016.12.002
Keywords
Heart development; Cell fate decisions; Retinoic acid; Retinoic acid receptors
Categories
Funding
- l'Institut de France Lefoulon-Delalande
- H-MSCA-IF
- INSERM
- Agence Nationale pour la Recherche [ANR-13-BSV2-0003-01]
- Association Francaise contre les Myopathies (AFM-Telethon)
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Substantial experimental and epidemiological data have highlighted the interplay between nutritional and genetic factors in the development of congenital heart defects. Retinoic acid (RA), a derivative of vitamin A, plays a key role during vertebrate development including the formation of the heart. Retinoids bind to RA and retinoid X receptors (RARs and RXRs) which then regulate tissue-specific genes. Here, we will focus on the roles of RA signaling and receptors in gene regulation during cardiogenesis, and the consequence of deregulated retinoid signaling on heart formation and congenital heart defects. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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