Journal
MECHANISMS OF DEVELOPMENT
Volume 144, Issue -, Pages 2-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2016.12.005
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Funding
- Plan Nacional [BFU2010-16546]
- Centro de Excelencia Severo Ochoa [SEV-2012-0208]
- 'La Caixa' PhD program
- CERCA Programme/Generalitat de Catalunya
- Spanish Ministry of Economy and Competitiveness
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Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process. In this review, we will describe the different forces acting in dorsal closure. We will present our current knowledge on the mechanisms generating and regulating these forces and report on the different quantitative mathematical models proposed so far. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.
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