Journal
MECHANISMS OF DEVELOPMENT
Volume 148, Issue -, Pages 79-88Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2017.04.006
Keywords
Cadherin; EMT; Xenopus; Cranial neural crest; Collective migration
Categories
Funding
- NIH/NIDCR [DE025692]
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Collective cell migration is a process whereby cells move while keeping contact with other cells. The Xenopus Cranial Neural Crest (CNC) is a population of cells that emerge during early embryogenesis and undergo extensive migration from the dorsal to ventral part of the embryo's head. These cells migrate collectively and require cadherin mediated cell-cell contact. In this review, we will describe the key features of Xenopus CNC migration including the key molecules driving their migration. We will also review the role of the various cadherins during Xenopus CNC emergence and migration. Lastly, we will discuss the recent and seemingly controversial findings showing that E-cadherin presence is essential for CNC migration. (C) 2017 Elsevier B.V. All rights reserved.
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