Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 161, Issue -, Pages 225-233Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.07.007
Keywords
Mitophagy; Signal transduction; Programmed cell death; Mitochondria; ERMES; Endoplasmic reticulum
Categories
Funding
- National Institutes of Health, USA [GM R15-113196, GM RO1-113052]
Ask authors/readers for more resources
Following extracellular stress signals, all eukaryotic cells choose whether to elicit a pro-survival or pro death response. The decision over which path to take is governed by the severity and duration of the damage. In response to mild stress, pro-survival programs are initiated (unfolded protein response, autophagy, mitophagy) whereas severe or chronic stress forces the cell to abandon these adaptive programs and shift towards regulated cell death to remove irreversibly damaged cells. Both pro-survival and pro-death programs involve regulated communication between the endoplasmic reticulum (ER) and mitochondria. In yeast, recent data suggest this inter-organelle contact is facilitated by the endoplasmic reticulum mitochondria encounter structure (ERMES). These membrane contacts are not only important for the exchange of cellular signals, but also play a role in mitochondrial tethering during mitophagy, mitochondrial fission and mitochondrial inheritance. This review focuses on recent findings in yeast that shed light on how ER-mitochondrial communication mediates critical cell fate decisions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available