Journal
MATRIX BIOLOGY
Volume 64, Issue -, Pages 6-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2017.03.004
Keywords
Extracellular matrix; Focal adhesion; Integrin; Mechanotransduction
Categories
Funding
- European Research Council [322652]
- Max Planck Society
- Max Planck Foundation
- German Research Council [SFB 863]
- European Research Council (ERC) [322652] Funding Source: European Research Council (ERC)
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The ability of cells to adhere and sense their mechano-chemical environment is key to many developmental, postnatal homeostatic and pathological processes; however, the underlying molecular mechanisms are still poorly understood. Here, we summarize recent progress that indicates how cell adhesion, mechanotransduction and chemical signaling are coordinated in cells, and we discuss how the combination of novel experimental approaches with theoretical studies is currently utilized to unravel the molecular mechanisms governing mechano-chemical coupling during cell adhesion. (C) 2017 The Authors. Published by Elsevier B.V.
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