Journal
FOOD & FUNCTION
Volume 10, Issue 2, Pages 836-848Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8fo02252f
Keywords
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Funding
- Cooperative Research Program for Agriculture Science Technology Development (Project title: Development of functional food materials based on soy germ extracts for postmenopausal syndrome) of the Rural Development Administration (RDA), Republic of Korea [PJ01243301]
- Cooperative Research Program for Agriculture Science & Technology Development (Project title: In vivo test and mechanism study menopausal women's health from soybean by-product) of the Rural Development Administration (RDA), Republic of Korea [PJ01243302]
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Obesity is a worldwide public health concern requiring safe and effective strategies. Recent studies suggest that bioactive compounds from soybeans have beneficial effects on weight loss and reducing fat accumulation. However, despite the biochemical and nutritional changes during germination, the biological effects of germinated soy germ have not been fully investigated. In this article, germinated soy germ extract (GSGE) was evaluated as a potential treatment option for obesity using 3T3-L1 pre-adipocyte and high-fat diet (HFD)-induced obese mice. In vitro studies demonstrated that GSGE suppressed the differentiation of 3T3-L1 cells into mature adipocytes, along with reductions in lipid accumulation and lipid droplet formation. In vivo studies also showed that a daily dose of 1 mg kg(-1) of GSGE reduced weight gain, adipocyte area, serum triglyceride, and LDL-cholesterol in HFD-fed mice. The GSGE treatment promoted browning, which was associated with increased UCP1 expression in vitro and in vivo. In addition, GSGE treatment induced beige fat activation by upregulation of lipolysis and beta-oxidation. Furthermore, gene and protein expression levels of endocannabinoid system-related factors such as NAPE-PLD, FAAH, DAGL-, and CB2 were altered along with browning and beige fat activation by GSGE. The present study indicates that GSGE effectively inhibits lipid accumulation and promotes beige fat transition and activation. Therefore, we suggest that GSGE treatment could be a promising strategy for the prevention of obesity by promoting weight loss, reducing fat accumulation, and improving obesity-related metabolic disorders.
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