Journal
FOOD & FUNCTION
Volume 10, Issue 2, Pages 903-911Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8fo01753k
Keywords
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Funding
- Project of National Key R&D Program of China, China [2017YFD0400900, 2017YFD0400904]
- Guangzhou Municipal Science and Technology Project, China [201707010043]
- Chinese Public Welfare Industry Special (Agriculture) Research, China [201503142-03]
- Guangdong Science and Technology Department, China [2017A070702007]
- Natural Science Foundation of Guangdong Province, China [2015A030312001]
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Pericarpium Citri Reticulatae (PCR, Citrus reticulata Chachi', Guangchenpi in Chinese) is one of the most famous Chinese citrus herbal medicines. The in vivo anti-asthmatic activity of Chachi' PCR was investigated using a histamine-induced experimental asthma model in Guinea pigs. Two alkaloid-type compounds, synephrine and stachydrine, were analyzed and identified in the Chachi' PCR alkaloid fraction. The alkaloid fraction and synephrine protected Guinea pigs against histamine-induced experimental asthma in a dose-dependent manner. The respective application of high, middle, and low doses of the Chachi' PCR alkaloid fraction significantly increased specific airway resistance by 284%, 328%, and 355%, and decreased dynamic compliance by 57%, 67%, and 75%. A similar change was observed for synephrine. The expression of eosinophils in bronchoalveolar lavage fluid (BALF) and serum IgE, IL-4, and IL-5 levels in histamine-induced experimental asthmatic Guinea pigs were significantly downregulated by the Chachi' PCR alkaloid fraction and synephrine compared to the control group, whereas stachydrine did not impart a statistically significant effect on the expression of tested inflammatory cells (leucocytes, eosinophils, neutrophils, and lymphocytes), immunoglobulin (IgE), or cytokines (IL-4 and IL-5). Pathological changes in lung tissues in each treatment group included the infiltration of inflammatory cells around the bronchia.
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