Journal
JOURNAL OF BREAST CANCER
Volume 22, Issue 1, Pages 77-85Publisher
KOREAN BREAST CANCER SOC
DOI: 10.4048/jbc.2019.22.e9
Keywords
Breast neoplasms; CD9 protein; human; Immunohistochemistry; Lobular carcinoma; Prognosis
Categories
Funding
- Medical Research Center Program [2015R1A5A2009124]
- National Research Foundation of Korea, Ministry of Science, ICT and Future Planning
Ask authors/readers for more resources
Purpose: We investigated the prognostic significance of CD9 expression in tumor cells of patients with invasive lobular carcinoma (ILC). Methods: CD9 expression was evaluated by immunohistochemistry in 113 ILC tissue samples. Correlation of CD9 expression with the patients' clinicopathological parameters and overall survival was assessed. Results: CD9 expression was detected in 48 (42.5%) ILC patients. However, no significant relation could be determined between CD9 expression and the clinicopathological parameters of the patient including tumor size, lymph node metastasis, lymphovascular invasion, histologic grade, expression of hormone receptors, human epidermal growth factor receptor 2 status, and Ki-67 labeling index. Patients with CD9 expression had worse overall survival (p = 0.051) and disease-free survival (DFS, p = 0.014) compared to patients without CD9 expression. Multivariate analysis revealed that CD9 expression was an independent prognostic factor for DFS (p = 0.049). Conclusion: CD9 expression in tumor cells could be a significant prognostic marker in patients with ILC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available