Journal
MATERIALS TODAY
Volume 20, Issue 10, Pages 577-591Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mattod.2017.06.005
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Funding
- NSF MME program grant [1642186]
- NIH Director's New Innovator Award [1DP2EB020549-01]
- NSF BME program grant [1510561]
- March of Dimes Foundation's Gene Discovery and Translational Research Grant
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1510561] Funding Source: National Science Foundation
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Four dimensional (4D) printing is an emerging technology with great capacity for fabricating complex, stimuli-responsive 3D structures, providing great potential for tissue and organ engineering applications. Although the 4D concept was first highlighted in 2013, extensive research has rapidly developed, along with more-in-depth understanding and assertions regarding the definition of 4D. In this review, we begin by establishing the criteria of 4D printing, followed by an extensive summary of state-of-the-art technological advances in the field. Both transformation-preprogrammed 4D printing and 4D printing of shape memory polymers are intensively surveyed. Afterwards we will explore and discuss the applications of 4D printing in tissue and organ regeneration, such as developing synthetic tissues and implantable scaffolds, as well as future perspectives and conclusions.
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