Journal
MATERIALS TODAY
Volume 20, Issue 1, Pages 32-44Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mattod.2016.07.001
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Funding
- National Natural Science Foundation of China [11372243, 11522219, 11532009, 81300696]
- International Science & Technology Cooperation Program of China [2013DFG02930]
- China Postdoctoral Science Foundation [2014M552463]
- Natural Science Foundation of Shaanxi Province of China [2015JM8471]
- Fundamental Research Funds for the Central Universities
- Key Program for International S&T Cooperation Projects of Shaanxi [2013KW33-01]
- Fundamental Research Funds for the Central Universities [xjj2014059]
- High Impact Research Grant [UM.C/HIR/MOHE/ENG/44]
- Fundamental Research Grant Scheme from the Ministry of Higher Education Malaysia. [FP054-2015A]
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Paper has recently attracted increasing attention as a substrate for various biomedical applications. By modifying its physical and chemical properties, paper can be used as an alternative to conventional cell culture substrates. Because it can be stacked into a three-dimensional (3D) structure, which can better mimic the in vivo cell microenvironment. Paper has shown great potential as a 3D cell culture platform for developing normal and diseased models. This platform gives precise control over extracellular matrix (ECM) composition as well as cell distribution and precise analysis of the interactions between cells. Paper-based platforms have been applied for pathophysiological studies and therapeutic intervention studies. In this paper, we first discuss the modifications of the physical and chemical properties of paper to develop various 2D and 3D cell culture platforms. We then review the applications of paper-based cell culture platforms for the construction of in vitro disease models, drug screening, and cell cryopreservation applications. Because of its advantages such as biocompatibility, eco-friendliness, cost efficiency, and ease of large-scale production, we believe that paper-based cell culture platforms would play an important role in the fields of biomedicine.
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