Journal
ALCOHOL
Volume 49, Issue 4, Pages 341-349Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2014.09.034
Keywords
Circadian; Dopamine; Alcohol; Addiction
Categories
Funding
- NIDA [DA023988]
- NIMH [MH082876]
- NIAAA [AA020452]
- NARSAD
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Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse. (C) 2015 Elsevier Inc. All rights reserved.
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