Journal
NANOSCALE
Volume 11, Issue 13, Pages 6285-6296Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr01122f
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Funding
- National Natural Science Foundation of China [81571747, 81771907]
- Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province
- Shanxi Scholarship Council of China [2015057]
- Key Research and Development Project of Shanxi Province [201703D321015-3]
- Science and Technology Innovation Team Project [201705D131026]
- Scientific and Technological Achievements Transformation Project of Shanxi Province [201704D131006]
- Shanxi Province Science Foundation for Youths [201701D221257]
- Foundation for PhD of Shanxi Medical University [03201620]
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Multimodality therapy under imaging-guidance is significant to improve the accuracy of cancer treatment. In this study, a photoacoustic imaging (PAI)-guided anticancer strategy based on poly-l-lysine functionalized melanin nanoparticles (MNP-PLL) was developed to treat laryngeal squamous cell carcinoma (LSCC). As a promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA nanoparticles were combined with photothermal ablation against primary tumors and miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor cells. Furthermore, taking advantage of the photoacoustic properties of melanin, PAI guided therapy could optimize the time point of NIR irradiation to maximize the efficacy of photothermal therapy (PTT). The in vitro and in vivo results proved that the combined treatments displayed the most significant tumor suppression compared with monotherapy. By integrating thermo-gene therapies into a theranostic nanoplatform, the MNP-PLL/miR-145-5p nanoparticles significantly suppressed the LSCC progression, indicating their great potential use for cancer therapy.
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