Journal
DALTON TRANSACTIONS
Volume 48, Issue 12, Pages 3914-3921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt00454h
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Funding
- National Science Foundation of China [21525105, 21778079]
- 973 Program [2015CB856301]
- Ministry of Education of China [IRT-17R111]
- Pearl River S&T Nova Program of Guangzhou [201806010136]
- Fundamental Research Funds for the Central Universities [17lgjc11]
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In this paper, the DNA interaction properties of four Ru(ii) polypyridyl complexes, [Ru(bpy)(2)(pip)](2+) (1), bpy = 2,2-bipyridine, pip = 2-phenyl-imidazo[4,5-f][1,10]phenanthroline, [Ru(bpy)(2)(nip)](2+) (2), nip = 2-naphthyl-imidazo[4,5-f][1,10]phenanthroline, [Ru(bpy)(2)(aip)](2+) (3), aip = 2-(9-anthryl)-imidazo[4,5-f][1,10]phenanthroline and [Ru(bpy)(2)(pyip)](2+) (4), pyip = 2-(1-pyrenyl)-imidazo[4,5-f][1,10]phenanthroline, were investigated by spectral titration. The intensity increases in the MLCT band of the complexes and the decrease in absorption due to the DNA secondary structure was attributed to DNA condensation by these complexes. The DNA condensing behavior of these complexes was investigated in more detail by gel electrophoresis (GAR), dynamic light scattering (DLS), zeta potential, atomic force microscopy (AFM), and transmission electron microscopy (TEM). The results suggest that the concentration of the complex plays a critical role in its DNA intercalating and DNA condensing behavior. Meanwhile, the aryl units in the ligands of complex 1-4 also have a large effect on their interactions with DNA.
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