Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 16, Issue 3, Pages 450-460Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.29935
Keywords
papillary thyroid cancer; molecular alteration; genetic signature; biomarker; diagnostics
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Funding
- University of Malaya [FG017-17AFR, BR002-2017]
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Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.
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