Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 78, Issue -, Pages 203-209Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.04.065
Keywords
Wound dressing; Hydrogel; Antibiotic delivery; Ocular drug delivery
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Funding
- University of Birmingham
- NIHR SRMRC Trauma Centre
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Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye drops on a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions. (C) 2017 Elsevier B.V. All rights reserved.
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