Journal
RSC ADVANCES
Volume 9, Issue 13, Pages 7203-7209Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra00616h
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Funding
- National Natural Science Foundation of China [21372068, 21572049]
- Science and Technology Program of Hunan Province, China [2014GK3115]
- Science and Technology Program of Changsha, China [K1508004-11]
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A convenient method for the synthesis of 2-oxo-acetamidines from methyl ketones using aromatic amines and DMF as nitrogen sources is reported via copper-catalyzed C(sp(3))-H amidination. Various methyl ketones react readily with aromatic amines and DMF, producing 2-oxo-acetamidines in yields of 47 to 92%. This protocol features the simultaneous formation of C-N and C?N bonds using DMF and aromatic amines as two different nitrogen sources. It thus provides an efficient approach to construct acyclic amidines via three C(sp(3))-H bond amidination. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.
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