Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 75, Issue -, Pages 259-271Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.02.075
Keywords
Antibacterial materials; Natural antibacterial materials; Microencapsulation of natural oil; Microencapsulation of eugenol; beta-cyclodextrine
Categories
Funding
- CNPq, Brazilian National Council for Scientific and Technological Development - Brazil [449376/2014-1, 453842/2014-3]
- Communitary University of the Chapeco Region - Unochapeco
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Eugenol is natural oil that has excellent antibacterial properties but cannot be used to fabricate many products that require thermal processing. One possible alternative to the use of the eugenol molecules in high temperature processes is the encapsulation of these molecules in a structure that is not toxic and is resistant to thermal treatment. This work investigated the encapsulation process of eugenol molecules in beta-cyclodextrine and the antibacterial properties of eugenol-beta-cyclodextrine (the eugenol-(beta CD complex) against Escherichia coli and Staphylococcus aureus. The FTIR, DSC, MEV and TGA results show that the encapsulation method is an excellent alternative to increase the thermal stability of eugenol molecules. A value of 241.32 Lmol(-1) was determined for the formation constant (Kc) of the eugenol-beta CD complex, which confirmed the success of the encapsulation process. The MEV analysis shows the formation of approximately 12 pm microcapsules. After the thermal treatment of the eugenol-beta CD complex at a temperature of 80 degrees C for 2 h, the complex retained significant antibacterial action, which confirms the thermal protection of the eugenol molecules. The minimum inhibitory concentration (MIC) and agar diffusion results show that the microcapsules containing 17.08 mmol.L-1 of eugenol exhibited excellent antibacterial action against Escherichia coli and Staphylococcus aureus after thermal treatment. (C) 2017 Elsevier B.V. All rights reserved.
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