Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 75, Issue -, Pages 1049-1058Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.03.014
Keywords
TiO2 nanotubes; Strontium; Silver; Bacterial resistance; Angiogenesis; Osteogenesis
Categories
Funding
- National Natural Science Foundation of China [31400815, 51671140]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [201626]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 11301215]
- City University of Hong Kong Strategic Research Grant (SRG) [7004644]
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Biomedical titanium (Ti) implants with good anti-infective, osteogenic, and angiogenic properties are in great demand. SrTiO3 nanotubes (NTs) are embedded with silver oxide (Ag2O) nanoparticles (NPs) (denoted as NT-Sr-Ag) by a hydrothermal treatment of TiO2 NTs containing Ag2O NPs (denoted as NT-Ag) in a Sr(OH)(2) solution. The morphology, composition, microstructure, ion release phenomenon, as well as antibacterial, osteogenic, and angiogenic activities are investigated in details. During the hydrothermal treatment, the amorphous TiO2 in the NTs morphs into cubic SrTiO3 gradually and the ordered nanotubular architecture is preserved. Some Ag2O NPs are incorporated into the structure although some of them dissolve in the solution. Long-term bacterial resistance against Staphylococcus aureus is observed as a result of the prolonged and controllable Ag+ release. NT-Sr-Ag can also release Sr2+ similarly to stimulate osteoblasts to secrete the vascular endothelial growth factor (VEGF). Both the released Sr2+ and secreted VEGF upregulate the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of osteoblasts. Furthermore, better angiogenic activity is observed when endothelial cells are cultured in NT-Sr-Ag conditioned media when compared with that in NT-Ag conditioned media, which is believed to be ascribed to the positive regulation of VEGF secretion of Sr2+.NT-2Sr-Ag and NT-3Sr-Ag (Hydrothermal treatment for 2 and 3 h, respectively) exhibit excellent antibacterial, osteogenic, and angiogenic activities and are promising in biomedical implants. (C) 2017 Elsevier B.V. All rights reserved.
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