Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 71, Issue -, Pages 452-459Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.10.039
Keywords
Mesoporous silica; Aldehyde functionalization; Drug delivery; Controlled release
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Funding
- National Natural Science Foundation of China [51102166, 51572172]
- Shanghai Shuguang Project [12SG39]
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We developed a potential pH-responsive protein drug delivery system based on aldehyde-functionalized dendritic mesoporous silica nanoparticles (DMSNs-CHO) as nanocarriers. The structure, protein drug loading and release behavior, in vitro cytotoxicity and cell uptake of the DMSNs-CHO nanoparticles were investigated. The results showed that the uniform DMSNs-CHO nanoparticles had an average particle size of 174 +/- 17 nm and a mesopore size of 7.7 nm. Using bovine serum albumin (BSA) as a model protein drug, BSA could be loaded into DMSNs-CHO nanoparticles owing to the formation of imine bonds between aldehyde groups and primary amines of BSA molecules. BSA loading capacity was about 136 mu g/mg, and BSA release from DMSNs-CHO nanocarriers was dependent on pH environment. Furthermore, the DMSNs-CHO nanoparticles had no cytotoxicity and could be efficiently taken up by cells. Therefore, the DMSNs-CHO nanoparticles would be promising as nanocarriers for pH-responsive delivery of protein drugs. (C) 2016 Elsevier B.V. All rights reserved.
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