Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 71, Issue -, Pages 1231-1240Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.11.014
Keywords
Chitosan; Ursolic acid; Liposomes; pH-responsive release; Antitumor
Categories
Funding
- National Natural Science Foundation [21476190]
- Hebei Province Key Basic Research Foundation [15961301D]
- Hebei Province Science and Technology Support Program [14277 7118D]
- Youth Foundation Project - Education Department, Hebei Province, China [QN2015034]
- Qinhuangdao Science and technology research and development Project [2012028029]
- Yanshan University graduate student innovation fund Project [2015XJSS052]
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There are tremendous challenges on antitumor and its therapeutic drugs, and preparation of highly efficient nano-vehicles represents one of the novel topics in antitumor pharmaceutical field. Herein, the novel chitosan-coated ursolic acid (UA) liposome (CS-UA-L) was efficiently prepared with highly tumor targeting, drug controlled release and low side-effect. The CS-UA-L was uniformly spherical particles with diameter of similar to 130 nm, and the size was more easily trapped into the tumor tissues. Chitosan modification can make liposomes carrying positive charges, which were inclined to combine with the negative charges on,the surface of tumor cells, and then the CS-UA-L could release UA rapidly at pH 5.0 comparing with pH 7.4. Meanwhile, the CS-UA-L exhibited obvious anti-proliferative effect (76.46%) on HeLa cells and significantly antitumor activity (61.26%) in mice bearing U14 cervical cancer. The tumor tissues of CS-UA-L treated mice had enhanced cell apoptosis, extensive necrosis and low cell proliferation activity. These results demonstrated that the multifunctional CS-UA-L allowed a precision treatment for localized tumor, and reducing the total drug dose and side-effect, which hold a great promise in new safe and effective tumor therapy. (C) 2016 Elsevier B.V. All rights reserved.
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