Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 76, Issue -, Pages 81-87Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.02.102
Keywords
Silk fibroin; Scaffold; Alginate microspheres; Nerve growth factor; Spinal cord injury
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Funding
- Scientific Research Cultivation and Innovation Fund [21615468]
- Administration of Traditional Chinese Medicine of Guangdong Province [20141067]
- High Level University Construction Funds [88016013032]
- Natural Science Foundation of China [31271019]
- Science and Technology Project of Guangdong [2011B031300006, 2016ZC0050]
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Neurons loss and axons degeneration after spinal cord injury (SCI) gradually give rise to result in functional motor and sensory impairment. A bridging biomaterial scaffold that allows the axons to grow through has been investigated for the repair of injured spinal cord. In this study, we introduced a silk fibroin (SF)-based neurobridge as scaffold enriched with/without nerve growth factor (NGF) that can be utilized as a therapeutic approach for spinal cord repair. NGF released from alginate (Alg) microspheres on SF scaffold (SF/Alg composites scaffolds) to the central lesion site of SCI significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons. This optimal multi-disciplinary approach of combining biomaterials, controlled-release microspheres and neurotrophic factors offers a promising treatment for the injured spinal cord. (C) 2017 Published by Elsevier B.V.
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