Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 72, Issue -, Pages 590-600Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.11.117
Keywords
Self-assembly; Aromatic amino acids; Supramolecular; Nanostructures; Amyloid
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Funding
- Science Engineering and Research Board (SERB) of India [SB/SO/BB/0040/2013]
- Department of Science & Technology (DST) PURSE grant II of India
- Department of Biotechnology (DBT) of India [BT/10460PFN/20/871/2013]
- University Grant Commission (UGC), India
- INSPIRE, DST, India
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In the pursuit for design of novel bio inspired materials, aromatic alpha-amino acids (phenylalanine, tyrosine, tryptophan and histidine) have been investigated for the generation of well-ordered self-assembled architects such as fibrils, rods, ribbons and twisted nanosheets in varying solvent systems. These nano/micro scaled architects were thoroughly characterized using FE-SEM, confocal microscopy, optical microscopy, H-1 NMR, FTIR, XRD and TGA. These self-assembled architects were histologically stained with Congo red and thioflavin T dyes for investigation of amyloid morphology which revealed that the deposited state of ordered assemblies exhibit specific characteristic of amyloid deposits. The self-assembly of aromatic amino acids was observed to be driven by non-covalent forces such as pi-pi stacking, van der Waals and electrostatic interaction. (C) 2016 Published by Elsevier B.V.
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