Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 71, Issue -, Pages 852-861Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.10.079
Keywords
Hydroxyapatite coating; Silver; Strontium; Antibacterial property; Bioactivity
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Funding
- National Natural Science Foundation of China [31370970]
- Tianjin Research Program of Application Foundation and Advanced Technology [13JCZDJC33300, 14JCQNJC03100]
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Implant-related infection in primary total joint prostheses has attracted considerable research attention, As a measure to improve the antimicrobial properties of implant materials, silver (Ag) was incorporated into calcium phosphate (CaP) coatings on Titanium (Ti) via a hydrothermal method. Further, strontium (Sr) was added as a binary dopant to reduce the cytotoxicity of Ag in the coatings. Results showed that the CaP coatings were uniformly deposited on Ti with enhanced hydrophilicity and nanoscale surface roughness. Moreover, cell adhesion, proliferation, and differentiation were improved after the CaP coating deposition, The antibacterial properties of the coatings were distinctly improved by the incorporation of Ag, but the cell proliferation and differentiation were significantly decreased. Owing to the incorporation of Sr, the Ag-CaP coatings were able to effectively counteract the negative effects of Ag while maintaining good antibacterial properties. In summary, hydrothermally deposited CaP coatings doped with Ag and Sr exhibit excellent biocompatibility and antimicrobial activity. Thus, such co-doped CaP coatings have considerable potential for orthopedic implant modification. (C) 2016 Elsevier B.V. All rights reserved.
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