Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 70, Issue -, Pages 303-310Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.09.001
Keywords
Halloysite; Alginate; Hydrogels; Biocompatibility; Bone tissue engineering
Categories
Funding
- National High Technology Research and Development Program of China [2015AA020915]
- National Natural Science Foundation of China [51473069, 51502113]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014606]
- Science and Technology Planning Project of Guangdong Province [2014A020217006]
- Guangdong Special Support Program [2014TQ01C127]
- Special Fund for Ocean-Scientific Research in the public interest [201405105]
- Pearl River S&T Nova Program of Guangzhou [201610010026]
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Sodium alginate (SA)/halloysite nanotubes (HNTs) composite hydrogels were successfully prepared by solution blending and cross-linking with calcium ions. HNTs can improve the physical properties and cytocompatibility of composite hydrogels. The static and shear viscosity of SA/HNTs solution increase by the addition of HNTs. FTIR suggests the presence of hydrogen bond interactions between HNTs and SA. The crystal structure of HNTs is retained in the composites as showed by the X-ray diffraction result A porous structure with pore size of 100250 is found in the hydrogels, which can provide a space for cell growth and migration. The compressive mechanical properties of composite hydrogels significantly increase compared to the pure SA hydrogel. The SA/ HNTs composite hydrogels with 80% HNTs loading exhibit the compressive stress at 80% strain of 2.99 MPa, while the stress at 80% strain of pure SA hydrogel is only 0.8 MPa. The dynamic storage modulus of composite hydrogels also maricedly increases with HNTs concentration. The differential scanning calorimetry endothermic peak area and swelling ratios in NaCl solution of the composite hydrogels decrease by the addition of HNTs. Preosteoblast (MC3T3-E1) culture results reveal that the SA/HNTs composites especially at relatively low HNTs loading show a significant increase in cells adhesion and proliferation compared to the pure SA hydrogel. All the results demonstrate that the SA/HNTs composite hydrogels show a promising application in bone tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
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