Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 79, Issue -, Pages 123-129Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.05.010
Keywords
Proteins; Transition metal dichalcogenides; Composites; Self-assembly; Biocompatibility
Categories
Funding
- National Natural Science Foundation of China [21274028, 21574023, 21574024]
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Photothermal therapy, due to its safety and effectiveness, has attracted tremendous interest in the area of cancer treatment in recent few decades. The emerging of two-dimensional transition metal dichalcogenides has provided this promising therapy with a novel genus of nanomaterials. Herein, we present a facile one-step way to prepare a hybrid of regenerated silk fibroin (RSF) and molybdenum disulfide (MoS2) nanosheets simply by directly adding MoS2 dispersion into RSF aqueous solution to induce the self-assembly of silk protein on the surface of MoS2 flakes. The produced RSF/MoS2 hybrids demonstrate better photothermal performance and less cytotoxicity than the pristine MoS2. In the meantime, the RSF/MoS2 hybrids show a good photothermal stability. Finally and importantly, the RSF/MoS2 hybrids display a satisfying photothermal capability on ablating HeLa cells in vitro, which imply that such a protein/inorganic hybrid material holds a great promise as a photothermal agent in future cancer treatment. (C) 2017 Elsevier B.V. All rights reserved.
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