Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 78, Issue -, Pages 349-353Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.04.100
Keywords
Microcapsule; Chlorhexidine; Silver nanoparticle; PLLA; Antibacterium
Categories
Funding
- National Key Basic Research Program of China [2013CB733804]
- National Natural Science Foundation of China for Key Project of International Cooperation [61420106012]
- Special Project on Development of National Key Scientific Instruments Equipment of China [2011YQ03013403]
- Collaborative Innovation Center of Suzhou Nano Science and Technology [SX21400213]
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In this study, composite antibacterial microcapsules combining of two antibacterial agents: chlorhexidine acetate and silver nanoparticle were prepared. The chlorhexidine acetate was encapsulated inside of the microcapsules and nano-sized silver particles were modified on the surface of microcapsules by electrostatic adsorption methods. Results show that this method decreases the silver usage dramatically, and promises a sustained antibacterial effect >30 days. These microcapsules can also be modified on the surface of polymer films easily, which demonstrated the potential in functionalizing the implanted materials with antibacterial property. (C) 2017 Published by Elsevier B.V.
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