Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 73, Issue -, Pages 357-365Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.12.039
Keywords
Self-healing; pH-sensitive; P(MVE-alt-MA); Inclusion complexation; Supramolecular hydrogel
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Funding
- National Basic Research Program of China [2011CB933503]
- program for New Century Excellent Talents in University [NCET-09-0298]
- Special Project on Development of National Key Scientific Instruments and Equipment of China [2011YQ03013403]
- Fundamental Research Funds for the Central Universities [CXLX13_118]
- National Natural Science Foundation of China [61179035, 61127002, 31200757]
- Suzhou Medical Apparatus and New Medicine Fund [ZXY201440]
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Self-healing materials are of interest for drug delivery, cell and gene therapy, tissue engineering, and other biomedical applications. In this work, on the base of biocompatible polymer poly(methyl vinyl ether-alt-maleic acid) (P(MVE-alt-MA)), host polymer p-cyclodextrin-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-beta-CD) and guest polymer adamantane-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-Ad) were first prepared. Then through taking advantage of the traditional host-guest interaction of p-cyclodextrin and adamantane, a novel self-healing pH-sensitive physical P(MVE-alt-MA)-g-beta-CD/P(MVE-alt-MA)-g-Ad supramolecular hydrogels were obtained after simply mixing the aqueous solution of host polymer and guest polymer. This kind of supramolecular hydrogels not only possess pH-sensitivity, but also possess the ability to repair themselves after being damaged. (C) 2016 Elsevier B.V. All rights reserved.
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