Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 80, Issue -, Pages 232-242Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.05.133
Keywords
Silk fibroin; Hydroxyapatite; Graphene oxide; Bone tissue engineering
Categories
Funding
- National Natural Science Foundation of China [21671204, 51203196, U1204510]
- Natural Science Foundation of Henan Province [162300410339]
- Program for Science & Technology Innovation Talents in Universities of Henan Province of China [15HASTIT024]
- Program for Science & Technology Innovation Teams in Universities of Henan Province of China [16IRTSTHN006]
- Plan for Scientific Innovation Talent of Henan Province [174100510013]
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To better mimic natural bone, a graphene oxide-hydroxyapatite/silk fibroin (cGO-HA/SF) scaffold was fabricated by biomineralizing carboxylated GO sheets, blending with SF, and freeze-drying. The material has increasing porosity and decreasing density from outside to inside. Analysis of GO mineralization in simulated body fluid indicated that carboxylation and Chitosan may synergistically regulate HA growth along the c-axis of weakly crystalline, rod-like GO-HA particles. Compared with HA/SF gradient composites, a cGO-HA gradient scaffold with cGO:HA mass ratio 1:4 has 5-fold and 2.5-fold higher compressive strength and compressive modulus, respectively. Additionally, the cGO-HA/SF composite stimulated mouse mesenchymal stem cell adhesion and proliferation, alkaline phosphatase secretion, and mineral deposition more strongly than HA/SF and pure HA scaffolds. Hence, the material may prove to be an excellent and versatile scaffold for bone tissue engineering. (C) 2017 Elsevier B.V. All rights reserved.
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