Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 70, Issue -, Pages 1120-1124Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.04.095
Keywords
Dental material; Ion release; Amorphous calcium phosphate; Hydroxyapatite
Categories
Funding
- National Natural Science Foundation of China [11272038, 31470915, 61227902]
- National Science & Technology Pillar Program of China [2012BAI18B01]
- Fundamental Research Funds for the Central Universities [YWF-16-BJ-Y-04]
- Pearl River S&T Nova Program of Guangzhou [2013J2200010]
- State Key Laboratory of New Ceramic and Fine Processing Tsinghua University
- 111 Project [B13003]
- International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China
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The aim of this study is to investigate the calcium and orthophosphate ions release during the transformation of amorphous calcium phosphate (ACP) to hydroxyapatite (HA) in aqueous solution. The ACP is prepared by a wet chemical method and further immersed in the distilled water for various time points till 14 d. The release of calcium and orthophosphate ions is measured with calcium and phosphate colorimetric assay kits, respectively. The transition of ACP towards HA is detected by x-ray diffraction (XRD), transmission electron microscopy (TEM), and fourier transform infrared spectroscopy (FTIR). The results indicate that the morphological conversion of ACP to HA occurs within the first 9 h, whereas the calcium and orthophosphate ions releases last for over 7 d. Such sustained calcium and orthophosphate ions release is very useful for ACP as a candidate material for hard tissue regeneration. (C) 2016 Elsevier B.V. All rights reserved.
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