Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 70, Issue -, Pages 788-795Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.09.033
Keywords
Antimicrobial polymer; Quaternized polyethyleneimine; Cross-linked polyethyleneimine; Structure-activity relationship; Staphylococcus aureus; Pseudomonas aeruginosa; Non-leaching coating
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Funding
- Russian Science Foundation [16-1400112]
- Russian Science Foundation [16-14-00112] Funding Source: Russian Science Foundation
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Novel quaternized polyethyleneimine and cross-linked polyethyleneimine derivatives have been synthesized using both traditional and microwave-assisted techniques to create antimicrobial coatings, with octyl, dodecyl, or hexadecyl bromides as alkylating agent and various bifunctional electrophiles as cross-linkers. Quaternization has been performed using methyl iodide or dimethyl sulfate; it has been shown that methyl iodide has no advantages over dimethyl sulfate. Antimicrobial activity of the polymers against Gram-positive (S. aureus) and Gram-negative (P. aeruginosa) bacteria has been evaluated. Antimicrobial activity declines with increase in the alkylating agent chain length. Equimolar ratio of the alkylating agent and the primary amino groups in polyethyleneimine is optimal. Although cross-linking decreases the antimicrobial activity of quaternized polyethyleneimines, it improves their non-leaching properties (i.e. minimizes undesirable water washout of the polymeric coatings). (C) 2016 Elsevier B.V. All rights reserved.
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