Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 70, Issue -, Pages 710-720Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.09.041
Keywords
Porifera skeleton; Bioactive-biomimetic material; Glycosaminoglycan; Alginate-based film; Environmentally sustainable formulation; Novel wound dressing
Categories
Funding
- M&B project: Valorization of marine biodiversity: Porifera as biomolecules/biomaterials sources and sustainable sponge mariculture [PRR-MAD-A2013-17630]
- project Preparation of [CUP E85E12000060009]
- BAMMBO Project - Sustainable Production of Biologically Active Molecules of Marine Based Origin [FP7 KBBE-2010-4-265896]
Ask authors/readers for more resources
The growing interest in the use of recyclable and biodegradable natural materials has become a relevant topic in pharmaceutics. In this work, we suggest the use and valorization of natural homy skeleton of marine sponges (Porifera, Dictyoceratida) as bio-based dressing for topical drug delivery. Biomaterial characterization focusing on morpho-functional traits, swelling behavior, fluid uptake performances, glycosaminoglycans content and composition andmicrobiological quality assessment was carried out to investigate the collagenic skeletonproperties. After grinding and sieving processes, L-cysteine hydrochloride-loaded formulations were designed in form of powder or polymeric film by testing various drug concentrations and different drying parameters. Drug content SEM analyses and in vitro permeation studies were performed to test the suitability of skeleton-based formulations. To this respect, drying time and temperature are key parameters for skeleton-mediated drug crystallization. Consequently, this behavior seems to influence drug loading and permeation profiles of formulations. The high percentages of drug are found after absorption into sponge powder and in vitro permeation studies demonstrate that cysteine is released more slowly than the pure drug within 1 h. Such a system is attractive because it combines the known healing properties of cysteine with the advantageous potentials of the collagen/proteoglycan network, which can act as biocompatible carrier able to absorb the excess of the wound exudate while releasing the drug. Furthermore, due to its glycosaminoglycans content, natural sponge skeletal scaffold might act as bioactive-biomimetic carrier regulating the wound healing processes. (C) 2016 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available