Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 79, Issue -, Pages 841-847Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.05.089
Keywords
Multi-walled carbon nanotubes; Methotrexate; Cyclophosphamide; Inter polymer complexes; Drug delivery
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By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH = 7.4 buffer (human body range) and pH = 4 buffer (pH of cancer cells), and fever temperature drug release kinetic was studied by different mathematical models. (C) 2017 Elsevier B.V. All rights reserved.
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