Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 81, Issue -, Pages 13-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.07.030
Keywords
Chitosan; Carboxymethyl cellulose; Microcapsule; Layer-by-layer assembly; Gas-liquid microfluidic approach
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Funding
- ESI Academic Development Program (WUT)
- Scientific Foundation for the Returned Overseas Chinese Scholars from State Education Ministry [47]
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In this work, a layer-by-layer (LbL) assembled biopolymer microcapsule with separate layer cavities is generated by a novel and convenient gas-liquid microfluidic approach. This approach exhibits combined advantages of microfluidic approach and LbL assembly method, and it can straightforwardly build LbL-assembled capsules in mild aqueous environments at room temperature. In particular, using this approach we can build the poly electrolyte multilayer capsule with favorable cavities in each layer, and without the need for organic solvent, emulsifying agent, or sacrificial template. Various components (e.g., drugs, proteins, fluorescent dyes, and nanoparticles) can be respectively encapsulated in the separate layer cavities of the LbL-assembled capsules. Moreover, the encapsulated capsules present the ability as colorimetric sensors, and they also exhibit the interesting release behavior. Therefore, the LbL-assembled biopolymer capsule is a promising candidate for biomedical applications in targeted delivery, controlled release, and bio-detection.
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