Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 80, Issue -, Pages 187-196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.05.143
Keywords
Microneedle; Insulin; Transdermal delivery; Diabetes
Categories
Funding
- National Natural Science Foundation of China [51373155]
- Science and Technology Innovation Program for College Students in Zhejiang Province [2016R406078]
- 521 Talents Training Plan in Zhejiang Sci-Tech University
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To reduce the inconvenient and painful of subcutaneous needle injection, the polymer microneedle patches that fabricated from modified alginate and hyaluronate were prepared for transdermal delivery of insulin. The as-prepared microneedles (MNs) exhibited excellent mechanical strength to penetrate the skin and good degradability to release loaded insulin. In vitro skin insertion capability was determined by staining with tissue-marking dye after insertion, and the real-time penetration depth was monitored using optical coherence tomography. Confocal microscopy images revealed that the rhodamine B and fluorescein isothiocyanate-labeled insulin (FITC-insulin) can gradually diffuse from the puncture sites to deeper tissue. In vivo and pharmacodynamic studies were then conducted to estimate the feasibility of the administration of insulin-loaded microneedle patches on diabetic mice for glucose regulation. The relative pharmacologic availability (RPA) and relative bioavailability (RBA) of insulin from microneedle patches were 90.5 +/- 6.8% and 92.9 +/- 7%, respectively. These results suggests the MNs developed in this study have a promising application in diabetes treatment via transdermal delivery. (C) 2017 Elsevier B.V. All rights reserved.
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