Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 76, Issue -, Pages 1136-1145Publisher
ELSEVIER
DOI: 10.1016/j.msec.2017.03.197
Keywords
Podophyllotoxin; Cyclodextrin; Inclusion complex; Characterization; Cytotoxic activity
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Funding
- NSFC [21162042, 21562048, 21662043]
- Innovative Team of Yunnan Minzu University
- Key Laboratory of Resource Clean Conversion in Ethnic Regions of Yunnan
- Changjiang Scholars and Innovative Research Team in University [IRT13095]
- Excellent Young Talents of Yunnan University
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The inclusion complexation behavior, characterization, and inclusion mode of podophyllotoxin (POD) with hydroxypropyl-beta-cyclodextrin (HP beta CD) were investigated in both solution and the solid state by means of XRD, DSC, SEM, H-1 and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of POD were obviously increased in the inclusion complex with HP beta CD. The cytotoxicity of POD/HP beta CD inclusion complex against all the human tumor cell lines investigated still remains. This satisfactory water solubility and high thermal stability of the POD/HP beta CD complex will be potentially useful for their application as herbal medicines or healthcare products. (C) 2017 Elsevier B.V. All rights reserved.
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